Miguel Lopez-Botet

Prof. Miguel López-Botet, MD PhD, was SNI president (2005-2008) and holds an appointment as Prof. emeritus at Univ. Pompeu Fabra (Barcelona). His interest on human NK cell biology started along the development of his PhD Thesis on T cell-mediated NK-like activity (1982), supervised by Prof. M. O. de Landázuri, and was reactivated by the generation in his lab of monoclonal antibodies leading to the identification of CD94 (1990-1993). Main past original contributions of the team include molecular and functional characterization of CD94/NKG2 and ILT2 (LILRB1) receptors for HLA class I molecules, accomplished in collaboration with other labs, and of the adaptive CD94/NKG2C+ NK cell response to human cytomegalovirus, whose implications have been explored in different clinical scenarios.